4  Early Death rate in APL

• Early death often from characteristic coagulopathy → start ATRA early, aggressively, correct w/ FFP, cryoprecipitate (fibrinogen >150 mg/dL), & PLT (plt >50K/μL)
• Characterstics and predictors Gill et al. (2021)

Gill, Harinder, Yammy Yung, Hiu-Tung Chu, et al. 2021. “Characteristics and Predictors of Early Hospital Deaths in Newly Diagnosed APL: A 13-Year Population-Wide Study.” Blood Advances 5 (14): 2829–38. https://doi.org/10.1182/bloodadvances.2021004789.